Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:21375
  • Symbol:Tbr1
  • Description:T-box brain transcription factor 1
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Gene ID Entry Entry Name Protein Name Type Information
21375 Q64336 TBR1_MOUSE T-box brain protein 1 (T-brain-1) (TBR-1) (TES-56) DISRUPTION PHENOTYPE Homozygous mutant mice do not nurse and die between postnatal days 1 and 3 (PubMed:9883721, PubMed:11239428). Brains are smaller than those of heterozygous or wild-type littermates, olfactory bulbs are small and olfactory bulb projection neurons are absent (PubMed:9883721). Mutant mice show severe defects of cortical development (PubMed:11239428). {ECO:0000269|PubMed:11239428, ECO:0000269|PubMed:9883721}.