| 21385 | Q60707 | TBX2_MOUSE | T-box transcription factor TBX2 (T-box protein 2) | DISRUPTION PHENOTYPE | Knockouts do not survive beyond embryonic 14.5 dpc (PubMed:15459098). Abnormal atrioventricular morphology at 9.5-10.5 dpc and outflow tract (OFT) septation defects in those surviving to 12.5 dpc (PubMed:15459098). Hindlimb digit duplication at 14.5 dpc (PubMed:15459098). Increased expression of CDKN1A, FRZB, IL33, SHISA3, and CCN4/WISP1 in lung mesenchyme between 12.5-14.5 dpc (PubMed:33731112). Conditional knockdown targeted mainly to lung mesenchyme causes lung hypoplasia at 18.5 dpc (PubMed:27720610). Conditional knockdown targeted mainly to the otic epithelium disrupts inner ear morphogenesis, which is exacerbated by simultaneous conditional knockdown of TBX3 (PubMed:33795231). Simultaneous conditional knockdown of TBX2 and TBX3 targeted mainly to lung mesenchyme causes severe bleeding from 10.5 dpc and embryos die shortly thereafter, perhaps as a result of knockdown in the developing heart (PubMed:27720610). {ECO:0000269|PubMed:15459098, ECO:0000269|PubMed:27720610, ECO:0000269|PubMed:33731112, ECO:0000269|PubMed:33795231}. |