| 21386 | P70324 | TBX3_MOUSE | T-box transcription factor TBX3 (T-box protein 3) | DISRUPTION PHENOTYPE | Conditional knockdown targeted mainly to lung mesenchyme causes lung hypoplasia at 18.5 dpc (PubMed:27720610). Conditional knockdown targeted mainly to the otic epithelium disrupts inner ear morphogenesis, which is exacerbated by simultaneous conditional knockdown of TBX2 (PubMed:33795231). Simultaneous conditional knockdown of TBX2 and TBX3 targeted mainly to lung mesenchyme causes severe bleeding from 10.5 dpc and embryos die shortly thereafter, perhaps as a result of knockdown in the developing heart (PubMed:27720610). {ECO:0000269|PubMed:27720610, ECO:0000269|PubMed:33795231}. |