| 21389 | P70327 | TBX6_MOUSE | T-box transcription factor TBX6 (T-box protein 6) | DISRUPTION PHENOTYPE | Defects in the differentiation of paraxial mesoderm. Irregular somites formed in the neck region of mutant embryos, whereas more posterior paraxial tissue did not form somites but instead differentiated along a neural pathway, forming neural-tube-like structures that flanked the axial neural tube. These paraxial tubes showed dorsal/ventral patterning that is characteristic of the neural tube and had differentiated motor neurons. Embryos lacking TBX6 show also randomization of the direction of heart looping and independent alterations in the direction of embryo turning. {ECO:0000269|PubMed:18575602, ECO:0000269|PubMed:21331042, ECO:0000269|PubMed:9490412}. |