| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 215061 | Q810I2 | TRI50_MOUSE | E3 ubiquitin-protein ligase TRIM50 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TRIM50) (Tripartite motif-containing protein 50) | DISRUPTION PHENOTYPE | TRIM50-deficient mice show a significantly prolonged survival time when LPS-challenged when compared with wild-type mice. TRIM50 deficiency also significantly ameliorates NLRP3-mediated inflammation and tissue damage in vivo. {ECO:0000269|PubMed:36178239}. |
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