| 21828 | Q9Z1T2 | TSP4_MOUSE | Thrombospondin-4 | DISRUPTION PHENOTYPE | On exposure to acute pressure overload, mice exhibit a marked increase in: heart weight and fibrosis, cardiomyocyte size and number of apoptotic cells in the myocardium, deposition of extracellular matrix (ECM) and levels of interstitial collagens. The increased ECM deposition is accompanied by changes in functional parameters of the heart and decreased vessel density. Mice also show defective induction of the ER stress response in the heart. Do not exhibit peripheral nerve injury-induced behavioral hypersensitivities such as thermal/mechanical hyperalgesia and tactile allodynia but show severe defects in cortical-injury-induced subventricular zone astrogenesis. {ECO:0000269|PubMed:22034490, ECO:0000269|PubMed:22362893, ECO:0000269|PubMed:22745497, ECO:0000269|PubMed:23615612}. |