| 21841 | P52912 | TIA1_MOUSE | Cytotoxic granule associated RNA binding protein TIA1 (Nucleolysin TIA-1) (RNA-binding protein TIA-1) (T-cell-restricted intracellular antigen-1) (TIA-1) | DISRUPTION PHENOTYPE | 50% lethality between embryonic day 16.5 and 3 weeks of age (PubMed:10921895). Surviving mice appear normal and live for around 2 years (PubMed:10921895). Increased production of TNF in macrophages after stimulation with lipopolysaccharides (LPS) (PubMed:10921895). Increased susceptibility to LPS-induced endotoxic shock (PubMed:10921895). {ECO:0000269|PubMed:10921895}. |