| 22242 | Q91X17 | UROM_MOUSE | Uromodulin (Tamm-Horsfall urinary glycoprotein) (THP) [Cleaved into: Uromodulin, secreted form] | DISRUPTION PHENOTYPE | Mice suffer significantly more frequently from urinary tract infections. They shown also spontaneous formation of calcium crystals in adult kidneys, and excessive intake of calcium and oxalate dramatically increases both the frequency and the severity of renal calcium crystal formation in mutant mice, but not in wild-type mice. {ECO:0000269|PubMed:14871399, ECO:0000269|PubMed:15327412}. |