| 22255 | O08934 | UNC4_MOUSE | Homeobox protein unc-4 homolog (Homeobox protein Uncx4.1) | DISRUPTION PHENOTYPE | Mice die perinatally and exhibit severe malformations of the axial skeleton. Pedicles of the neural arches and proximal ribs are not formed. In addition, dorsal root ganglia are disorganized. In the hypothalamo-neurohypophysial system, neurons are viable and able to express neuropeptides; however, the connectivity of magnocellular neurons with posterior pituitary elements is compromised. {ECO:0000269|PubMed:10804168, ECO:0000269|PubMed:10804169, ECO:0000269|PubMed:16461927}. |