Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:225865
  • Symbol:Catsper1
  • Description:cation channel, sperm associated 1
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Gene ID Entry Entry Name Protein Name Type Information
225865 Q91ZR5 CTSR1_MOUSE Cation channel sperm-associated protein 1 (CatSper1) DISRUPTION PHENOTYPE Mice are normal but males are sterile. Male sterility is due to defects in sperm motility unability to fertilize intact eggs. In mice lacking Catsper1, sperm lacks CatSper2 protein, while in mice lacking CatSper1, sperm lacks CatSper1 protein, suggesting that stable expression of CatSper1 protein requires CatSper2 and vice versa. {ECO:0000269|PubMed:11595941}.