| 22612 | Q04736 | YES_MOUSE | Tyrosine-protein kinase Yes (EC 2.7.10.2) (Proto-oncogene c-Yes) (p61-Yes) | DISRUPTION PHENOTYPE | Knouckout mice show reduced OCT2 tyrosine phosphorylation and reduced OCT2-mediated TEA renal secretion (PubMed:26979622). Knouckout mice are protected from oxaliplatin-induced acute sensory neuropathy (PubMed:26979622). Mice are viable, fertile, and display no apparent phenotypes. This lack of phenotype may be attributable to compensatory roles of the other SRC-family members. {ECO:0000269|PubMed:26979622, ECO:0000269|PubMed:7958873}. |