Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:22670
  • Symbol:Trim26
  • Description:tripartite motif-containing 26
Export (tab separated) Export to Excel
Gene ID Entry Entry Name Protein Name Type Information
22670 Q99PN3 TRI26_MOUSE Tripartite motif-containing protein 26 (EC 2.3.2.27) (Zinc finger protein 173) DISRUPTION PHENOTYPE TRIM26 attenuatess the production of proinflammatory cytokines in response to TLR ligands, TNF-alpha, and IL-1beta stimulation. In addition, the challenge of TRIM26-deletion mice with LPS results in inflammatory responses that are less lethal than those in wild-type mice. {ECO:0000269|PubMed:34017102}.