| 22671 | Q96DY5 | RN112_MOUSE | RING finger protein 112 (EC 2.3.2.27) (Brain finger protein) (Neurolastin) (Zinc finger protein 179) | DISRUPTION PHENOTYPE | Embryos exhibit blood vascular defects and die in utero. The survivors manifest growth retardation as indicated by smaller size and a reduced weight, and display impairment of brain functions including motor balance, and spatial learning and memory (PubMed:26951452). Mice exhibit a reduction in the size of brains, reduced dendritic spine density, impaired synaptic transmission and reduced levels of antioxidant enzymes in the hippocampus (PubMed:26792191, PubMed:26212327). Knockdown of RNF112 diminishes neuronal differentiation, glial differentiation and dendritic arborization in primary cerebellar granule cells (PubMed:28684796, PubMed:21566658). {ECO:0000269|PubMed:21566658, ECO:0000269|PubMed:26212327, ECO:0000269|PubMed:26792191, ECO:0000269|PubMed:26951452, ECO:0000269|PubMed:28684796}. |