| Gene ID | Entry | Entry Name | Protein Name | Type | Information | 229644 | Q6PFY8 | TRI45_MOUSE | E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99) (Tripartite motif-containing protein 45) | DISRUPTION PHENOTYPE | Deletion mutant mice show earlier onset of death and exhibit higher mortality in response to lethal challenge with LPS. The production of TNF-alpha, IL-6, and IL-1beta is also significantly up-regulated after TLR challenge. {ECO:0000269|PubMed:36681779}. |
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