| 229898 | Q8CFB4 | GBP5_MOUSE | Guanylate-binding protein 5 (EC 3.6.5.-) (GTP-binding protein 5) (GBP-5) (MuGBP-5) (Guanine nucleotide-binding protein 5) | DISRUPTION PHENOTYPE | Mutant mice exhibit impaired host defense and NLRP3-dependent inflammatory responses. During LPS-induced sepsis, knockout animals show 60 to 75% reduction in IL1B and IL-18 serum levels compared to wild-type mice. Orogastric challenge with Listeria monocytogenes leads to higher bacterial burdens, discernible weight loss, and 50 to 80% fewer leukocytes expressing active CASP1 in mesenteric lymph nodes compared to wild-type counterparts. {ECO:0000269|PubMed:22461501}. |