| 229900 | Q91Z40 | GBP7_MOUSE | Guanylate-binding protein 7 (EC 3.6.1.-) (EC 3.6.5.-) (GTP-binding protein 7) (GBP-7) (Guanine nucleotide-binding protein 7) (Guanylate-binding protein 4-like) | DISRUPTION PHENOTYPE | Mice show a dramatic susceptibility to T. gondii infection, resulting in rapid death of infected mice in the acute phase of infection. A significantly increased parasite load seen in the spleen, liver and the peritoneal fluid, with markedly elevated production of pro-inflammatory cytokines and development of severe ascites. {ECO:0000269|PubMed:31964735}. |