Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:231600
  • Symbol:Chfr
  • Description:checkpoint with forkhead and ring finger domains
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Gene ID Entry Entry Name Protein Name Type Information
231600 Q810L3 CHFR_MOUSE E3 ubiquitin-protein ligase CHFR (EC 2.3.2.27) (Checkpoint with forkhead and RING finger domains protein) (RING-type E3 ubiquitin transferase CHFR) DISRUPTION PHENOTYPE Mice are viable and have no obvious developmental defects. They are however cancer-prone and develop spontaneous tumors. They also display increased skin tumor incidence after treatment with dimethylbenz(a)anthracene. {ECO:0000269|PubMed:15793587}.