| 234854 | Q3UMM4 | CDK10_MOUSE | Cyclin-dependent kinase 10 (EC 2.7.11.22) (Cell division protein kinase 10) | DISRUPTION PHENOTYPE | CDK10 knockout results in partial prenatal lethality. Surviving mice display severe growth retardation, a reduced volume of mineralized matrix in the head, femur, tibia and fibula, bifidity or clefting of C1 (atlas) or C2 (axis), and absence of the dens. Additional defects are present in the kidney, lung, heart, spleen, liver, and muscle. At cellular level, CDK10 knockout does not affect cell proliferation. However, knocked-out mouse embryonic fibroblasts (MEFs) develop longer cilia. {ECO:0000269|PubMed:28886341}. |