Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:23797
  • Symbol:Akt3
  • Description:thymoma viral proto-oncogene 3
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Gene ID Entry Entry Name Protein Name Type Information
23797 Q9WUA6 AKT3_MOUSE RAC-gamma serine/threonine-protein kinase (EC 2.7.11.1) (Protein kinase Akt-3) (Protein kinase B gamma) (PKB gamma) (RAC-PK-gamma) DISRUPTION PHENOTYPE Results in the cytoplasmic accumulation of the master regulator of mitochondrial biogenesis, Ppargc1a, and a reduction in known Ppargc1a target genes, which leads to an abnormal mitochondrial phenotype in the brain tissue. {ECO:0000269|PubMed:18524868}.