Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:238377
  • Symbol:Gpr68
  • Description:G protein-coupled receptor 68
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Gene ID Entry Entry Name Protein Name Type Information
238377 Q8BFQ3 OGR1_MOUSE Ovarian cancer G-protein coupled receptor 1 (G-protein coupled receptor 68) (Sphingosylphosphorylcholine receptor) DISRUPTION PHENOTYPE Mice have reduced osteoclasts derived from bone marrow cells, a pH-dependent osteoclast survival effect is also detected. However, the overall bone structures of the mice are not affected. In addition melanoma cell tumorigenesis is significantly inhibited. {ECO:0000269|PubMed:19479052}.