| 239102 | Q2MHN3 | ZFHX2_MOUSE | Zinc finger homeobox protein 2 (Zinc finger homeodomain protein 5) | DISRUPTION PHENOTYPE | Knockout mice exhibit a range of subtle behavioral abnormalities. Locomotor activity is generally increased, but only in familiar environments. There is a slight increase in depression-like behavior, most notably increased immobility in the tail suspension test. Assays of anxiety-like behavior give conflicting results; the open field test indicates a slight reduction in anxiety-like behavior whereas other tests show no significant behavioral changes (PubMed:23300874). Knockout mice are hyposensitive to noxious mechanical stimuli applied to the tail and hypersensitive to noxious heat (PubMed:29253101). {ECO:0000269|PubMed:23300874, ECO:0000269|PubMed:29253101}. |