| 241324 | Q80YA8 | CRUM2_MOUSE | Protein crumbs homolog 2 (crumbs2) (Crumbs-like protein 2) | DISRUPTION PHENOTYPE | Embryonic lethality due impaired gastrulation (PubMed:22072575, PubMed:27870829). Mesoderm formation is disrupted, and cells do not ingress (PubMed:27870829). Instead, a single layer forms, and the embryo fails to properly establish its body plan, leading to embryonic arrest (PubMed:27870829). Conditional deletion in the developing retina leads to progressive disorganization during late retinal development: retina show progressive thinning of the photoreceptor layer and sites of cellular mislocalization (PubMed:23001562). Conditional deletion in the dorsal telencephalon leads to defects in the maintenance of the apical complex (PubMed:26802325). {ECO:0000269|PubMed:22072575, ECO:0000269|PubMed:23001562, ECO:0000269|PubMed:26802325, ECO:0000269|PubMed:27870829}. |