| 246177 | Q5SUA5 | MYO1G_MOUSE | Unconventional myosin-Ig | DISRUPTION PHENOTYPE | T-cells display impaired migration patterns and are less efficient in scanning and evaluating antigen-presenting cells. T-cells show global reduction in membrane tension, while their homeostatic tissue distribution and responsiveness to T-cell receptor (TCR) engagement are unaffected. However, T-cells move faster and straighter, leading to defects in detection of antigen-presenting cells, specifically for detection of rare antigens. {ECO:0000269|PubMed:25083865}. |