| 252972 | Q9EQJ0 | TPC1_MOUSE | Two pore calcium channel protein 1 (Voltage-dependent calcium channel protein TPC1) | DISRUPTION PHENOTYPE | TPCN1 and TPCN2 double knockouts are viable, fertile, have no obvious morphological abnormalities, and no obvious behavioral defects. After fasting for 3 days, they are less active and endurance performance is reduced by 8.3 fold in contrast to wild-type littermates that show no changes. Two days after re-introduction of food, mutants regain endurance and become as active as before fasting. {ECO:0000269|PubMed:23394946}. |