Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:258658
  • Symbol:Olfr734
  • Description:olfactory receptor 734
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Gene ID Entry Entry Name Protein Name Type Information
258658 Q8VFT4 OL734_MOUSE Olfactory receptor 734 DISRUPTION PHENOTYPE Compared to wild-type mice, mutant mice fed on a regular diet show a remarkable decrease in body weight, food intake, fat mass and plasma lipids (PubMed:31230984). Blunted response to Asprosin, including attenuated cAMP levels and hepatic glucose production, as well as improved insulin sensitivity (PubMed:31230984). Mutant mice show significantly reduced food intake in overnight-fasted mice compared with wild-type mice (PubMed:32337066). Male mice display decreased fertility caused by impaired sperm motility (PubMed:31798959). {ECO:0000269|PubMed:31230984, ECO:0000269|PubMed:31798959, ECO:0000269|PubMed:32337066}.