| 26365 | P31809 | CEAM1_MOUSE | Carcinoembryonic antigen-related cell adhesion molecule 1 (Biliary glycoprotein 1) (BGP-1) (Biliary glycoprotein D) (MHVR1) (Murine hepatitis virus receptor) (MHV-R) (CD antigen CD66a) | DISRUPTION PHENOTYPE | Knockout mice exhibit impairment of insulin clearance and hyperinsulinemia, which cause insulin resistance; develop insulin resistance primarily in liver (PubMed:18544705). Display normal white blood cell, red blood cell, hemoglobin and platelet. On the other hand, mice have a high number of neutrophils. Display also increased thrombus growth, and enhanced susceptibility to type I collagen induced pulmonary thromboembolism (PubMed:19008452). Spontaneously develop systemic neutrophilia. Upon Listeria Monocytogenes (LM) infection mice die dramatically faster within 7 days and display an improved bacterial clearance accompanied by severe tissue damage and necrosis in the liver (PubMed:21029969). Knockout mice present an increased basal permeability (PubMed:21081647). Knockout mice show a reduced bone mass namely a decreased trabecular bone volume accompanied by a reduction in trabecular number and an increase in trabecular separation (PubMed:25490771). {ECO:0000269|PubMed:18544705, ECO:0000269|PubMed:19008452, ECO:0000269|PubMed:21029969, ECO:0000269|PubMed:21081647, ECO:0000269|PubMed:25490771}. |