| 268780 | Q4VBE4 | EGFLA_MOUSE | Pikachurin (EGF-like, fibronectin type-III and laminin G-like domain-containing protein) (Nectican) | DISRUPTION PHENOTYPE | No morphological abnormalities. Knockout mice are viable and fertile. However, the terminal of bipolar cells do not appose to the synapse terminals in the rod photoreceptor ribbon synapses. The signal transmission from the rod photoreceptor to the rod bipolar cells is less sensitive and is delayed compared to the wild type mouse. The signal transmission from cone photoreceptors to the cone bipolar cells is also impaired. These mice show reduced visual function. {ECO:0000269|PubMed:18641643}. |