| 268935 | Q66PY1 | SCUB3_MOUSE | Signal peptide, CUB and EGF-like domain-containing protein 3 | DISRUPTION PHENOTYPE | Knockout mice are viable and do not show any macroscopically visible abnormality at birth. At day P1, however, knockout mice are shorter than their control littermates, and show misaligned upper/lower incisors and altered craniofacial development. All appendicular (forelimbs and hindlimbs) and axial (skull, vertebral column, and rib cage) skeletal elements are smaller than in control animals. The defective skeletal growth persists up to adulthood. {ECO:0000269|PubMed:33308444}. |