| 269152 | Q7TNC6 | KI26B_MOUSE | Kinesin-like protein KIF26B | DISRUPTION PHENOTYPE | Mutant mice die within 24 hours after birth. Most mice show bilateral kidney agenesis. The development of other organs seems normal. Ureteric bud attraction is impaired after 11.0 dpc. The ureteric buds are attracted close to the mesenchyme but fail to invade and branch into the mesenchyme and the kidney disappears by 14.5 dpc. The mesenchymal cells undergo apoptotic cell death at 12.5 dpc. ITGA8 is reduced at the ureteric bud/mesenchyme junction and does not exhibit basolateral localization. GDNF is not properly maintained in the mesenchyme at 11.5 dpc. {ECO:0000269|PubMed:20439720}. |