| 29813 | Q8VD12 | Z385A_MOUSE | Zinc finger protein 385A (Hematopoietic zinc finger protein) | DISRUPTION PHENOTYPE | No visible phenotype at birth. Between 2-3 weeks after birth, some lethality is observed, may be due to internal hemorrhaging mainly in brain and gastrointestinal tracts. Surviving mutants are fertile and smaller than their wild-type littermates. Deficiency alters hemostasis which is associated with a block in the formation of alpha-granules in megakaryocytes and abnormal platelet morphology. Mice also exhibit tremor, ataxic gate, tilted head, severe impairments in motor coordination and motor learning related to cerebellar functions. Mice show functional deregulation of adipose tissues, although the total fat mass is not affected. They express lower levels of C/EBP alpha in adipose tissue, have impaired glucose tolerance with high plasma insulin levels and plasma adiponectin levels are significantly lower. Upon genotoxic stress, skin and prostate show increased apoptosis. {ECO:0000269|PubMed:11927637, ECO:0000269|PubMed:17383763, ECO:0000269|PubMed:18418387}. |