| 30955 | Q9JHG7 | PK3CG_MOUSE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PI3-kinase subunit gamma) (PI3K-gamma) (PI3Kgamma) (PtdIns-3-kinase subunit gamma) (EC 2.7.1.137) (EC 2.7.1.153) (EC 2.7.1.154) (Phosphatidylinositol 4,5-bisphosphate 3-kinase | DISRUPTION PHENOTYPE | PIK3CG-null mice are viable and fertile, and display immunological abnormalities when the immune system is stressed. There is reduced T(reg) cells amount, reduced levels of IgG, enhanced IL12 production in macrophages, and increased T-cell infiltration in the gut (PubMed:31554793). Leukocyte migration in response to chemotactic agents and towards the site of inflammation, as well as neutrophil oxidative burst in response to chemotactic agents are decreased. Mutant mice show reduced thymocyte survival, defective T lymphocyte activation, and are protected from leukocyte infiltration of synovia in a model of rheumatoid arthritis. Dendritic cell showed reduced response to chemokines and migration to draining lymph nodes under inflammatory conditions. Platelets have defects in thrombus formation. PIK3CG-null mice show increased cardiac contractility, and display myocardial damage after transverse aortic constriction. {ECO:0000269|PubMed:10669416, ECO:0000269|PubMed:10669418, ECO:0000269|PubMed:12297047, ECO:0000269|PubMed:15294162, ECO:0000269|PubMed:15318168, ECO:0000269|PubMed:16127437, ECO:0000269|PubMed:17673465, ECO:0000269|PubMed:31554793}. |