| 319197 | Q8BUD0 | GPR4_MOUSE | G-protein coupled receptor 4 | DISRUPTION PHENOTYPE | Deficient mice display partial neonatal and postnatal lethality, hemorrhages, impaired association of vascular smooth muscle cells with capillaries and small arteries and veins, and impaired contact between mesangial cells and renal glomerular capillaries (PubMed:17145776). The inflammatory response is reduced in an inflammatory hindlimb ischemia-reperfusion model (PubMed:26068853). Deficient mice display reduced central respiratory chemoreflex, increased apnea frequency, and blunted ventilatory responses to CO2 (PubMed:32058960). {ECO:0000269|PubMed:17145776, ECO:0000269|PubMed:26068853, ECO:0000269|PubMed:32058960}. |