| 319229 | Q5FWI2 | SCTR_MOUSE | Secretin receptor (SCT-R) | DISRUPTION PHENOTYPE | Mice are overtly normal and fertile (PubMed:17008357). Mice however display impaired synaptic plasticity in the hippocampus: the number of dendritic spines in the CA1 hippocampal pyramidal cells is slightly reduced and mice show abnormal social behavior (PubMed:17008357). Mice are not hyperphagic and display normal food intake (PubMed:24769669). Following a 12 week high-fat diet, knockout mice gain significantly less weight and exhibit lower body fat content, possibly caused by reduced fat absorption in the intestine (PubMed:24769669). Mice also show mild polydipsia and polyuria; kidney display altered glomerular and tubular morphology (PubMed:17283064). {ECO:0000269|PubMed:17008357, ECO:0000269|PubMed:17283064, ECO:0000269|PubMed:24769669}. |