Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:319387
  • Symbol:Adgrl3
  • Description:adhesion G protein-coupled receptor L3
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Gene ID Entry Entry Name Protein Name Type Information
319387 Q80TS3 AGRL3_MOUSE Adhesion G protein-coupled receptor L3 (Latrophilin-3) (Lectomedin-3) DISRUPTION PHENOTYPE Mutant mice are viable and present no obvious physical phenotype. Compared to wild-type, mutants are hyperactive, and their dorsal striatum contains higher levels of the neurotransmitters dopamine and serotonin. Cocaine treatment causes a higher increase in locomotor activity than in wild-type. {ECO:0000269|PubMed:22575564}.