| 320398 | Q6P1C6 | LRIG3_MOUSE | Leucine-rich repeats and immunoglobulin-like domains protein 3 (LIG-3) | DISRUPTION PHENOTYPE | Mice display circling and head tossing behavior, due to a defect in inner ear morphogenesis. In mutants, fusion of the canal pouches starts earlier than normal and involves an abnormally large region, leading to truncation of the lateral semicircular canal in the inner ear. Nevertheless, hearing seems to be normal. Mutant mice also display craniofacial deformities, and especially a dramatically shortened snout. {ECO:0000269|PubMed:19004851, ECO:0000269|PubMed:20126551}. |