| 321019 | Q3U6B2 | GP183_MOUSE | G-protein coupled receptor 183 (Epstein-Barr virus-induced G-protein coupled receptor 2 homolog) (EBI2) (EBV-induced G-protein coupled receptor 2 homolog) | DISRUPTION PHENOTYPE | Mice display a reduction in the early antibody response to a T-dependent antigen (PubMed:19597478). B-cells fail to move to the outer follicle at day 2 of activation, and instead are found in the follicle center (PubMed:19615922). Mice have normal numbers of B- and T-cells and organized follicles and T-cell compartments are present (PubMed:19615922). Mice show a decreased number of splenic CD4(+) dendritic cells and defective priming of T- and B-cell response (PubMed:23682316, PubMed:23502855). Reduced follicular helper T (Tfh) cells (PubMed:27147029). T-cells fail to accumulate in the outer T zone at either time point and instead remain dispersed throughout the T zone (PubMed:27147029). {ECO:0000269|PubMed:19597478, ECO:0000269|PubMed:19615922, ECO:0000269|PubMed:23502855, ECO:0000269|PubMed:27147029}. |