| 330790 | Q80WM4 | HPLN4_MOUSE | Hyaluronan and proteoglycan link protein 4 (Brain link protein 2) | DISRUPTION PHENOTYPE | In deep cerebellar nuclei (DCN) neurons of knockout mice, inhibitory synaptic strengths are reduced as compared to those in wild-type mice, whereas the properties of excitatory synapses are unaffected (PubMed:30125937). A reduction in GABAergic pre-synaptic terminals of Purkinje cells are seen in the DCN neurons (PubMed:30125937). Mice show significantly attenuated perineuronal nets formation in the DCN, a marked decrease of brevican (BCAN) in the brainstem and cerebellum and a reduction in synapse number in the DCN neurons (PubMed:22121037). {ECO:0000269|PubMed:22121037, ECO:0000269|PubMed:30125937}. |