| 330814 | Q80TR1 | AGRL1_MOUSE | Adhesion G protein-coupled receptor L1 (Calcium-independent alpha-latrotoxin receptor 1) (CIRL-1) (Latrophilin-1) (Lectomedin-2) | DISRUPTION PHENOTYPE | Knockout animals are born at sub-Mendelian ratios. ADGRL1-null mice who survive to adulthood demonstrate stereotypic behaviors, sexual dysfunction, bimodal extremes of locomotion, augmented startle reflex, and attenuated pre-pulse inhibition, which respond to risperidone. Ex vivo synaptic preparations display increased spontaneous exocytosis of dopamine, acetylcholine, and glutamate, although ADGRL1-deficient neurons poorly form synapses in vitro. {ECO:0000269|PubMed:35907405}. |