| 50754 | Q8VBV4 | FBXW7_MOUSE | F-box/WD repeat-containing protein 7 (F-box and WD-40 domain-containing protein 7) (F-box protein FBW7) (F-box protein Fbxw6) (F-box-WD40 repeat protein 6) (SEL-10) | DISRUPTION PHENOTYPE | Whole body FBW7 knockout is embryonic lethal. Conditional knockout mice in which FBW7 expression is specifically abolished in osteoclasts display severe bone resorption, bone fragility and low bone mass (PubMed:29149593). Conditional knockout in liver reduces the amplitude of the diurnal expression of many core clock genes and the altered expression of a large number of genes controlling liver metabolic pathways (PubMed:27238018). {ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:29149593}. |