| 53610 | Q99K48 | NONO_MOUSE | Non-POU domain-containing octamer-binding protein (NonO protein) | DISRUPTION PHENOTYPE | Mutant mice display flattened nose and a smaller cerebellum. Behaviorally, mice show impaired spatial memory, as well as a marked anxiety phenotype and increased risk aversion (PubMed:26571461). Deletion leads to a significant dissociation of TET1 from chromatin and dysregulation of DNA hydroxymethylation of neuronal genes (PubMed:32286661). {ECO:0000269|PubMed:26571461, ECO:0000269|PubMed:32286661}. |