Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:53859
  • Symbol:Map3k14
  • Description:mitogen-activated protein kinase kinase kinase 14
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Gene ID Entry Entry Name Protein Name Type Information
53859 Q9WUL6 M3K14_MOUSE Mitogen-activated protein kinase kinase kinase 14 (EC 2.7.11.25) (NF-kappa-beta-inducing kinase) (Serine/threonine-protein kinase NIK) DISRUPTION PHENOTYPE Mice display the alymphoplasia phenotype (aly), which is characterized by systemic absence of lymph nodes and Peyer patches and disorganized splenic and thymic structures with immunodeficiency. {ECO:0000269|PubMed:10319865}.