| 54383 | Q9QWH1 | PHC2_MOUSE | Polyhomeotic-like protein 2 (mPH2) (Early development regulatory protein 2) (p36) | DISRUPTION PHENOTYPE | Mice are viable and fertile but show posterior transformations of the axial skeleton and premature senescence of mouse embryonic fibroblast associated with derepression of Hox cluster genes and Cdkn2a genes, respectively. Mice lacking Phc2 and Phc1 die at an early gestational stage. Mice mutant for Phc1 and/or Phc2 demonstrate that Phc1 and Phc2 mutations affect synergistically the survival of embryos in a gene dosage-dependent manner and thus show functional redundancy of Phc1 and Phc2. {ECO:0000269|PubMed:16024804}. |