| 545370 | D3YXG0 | HMCN1_MOUSE | Hemicentin-1 (Fibulin-6) (FIBL-6) | DISRUPTION PHENOTYPE | Mutants are viable and fertile with no gross phenotypes (PubMed:32035013, PubMed:34504132). Ultrastructural basement membrane alterations are observed at dermal-epidermal and myotendinous junctions (PubMed:34504132). However, another study showed that embryos arrest between the one- and four-cell stages with cleavage furrows that form but fail to ingress and often retract prior to completion, resulting in multinucleate cells (PubMed:21215633). Double knockout of Hmcn1 and Hmcn2 results in no overt phenotypes with mice being viable and fertile (PubMed:32035013). {ECO:0000269|PubMed:21215633, ECO:0000269|PubMed:32035013, ECO:0000269|PubMed:34504132}. |