| 54698 | Q149L7 | CRTAM_MOUSE | Cytotoxic and regulatory T-cell molecule (Class-I MHC-restricted T-cell-associated molecule) (CD antigen CD355) | DISRUPTION PHENOTYPE | No visible phenotype (PubMed:18329370, PubMed:19752223). In the small intestine mucosa and under steady-state conditions, severe reduction in the number of intraepithelial CD4+ CD8+ T-cells and, partial reduction in the number of lamina propria and intraepithelial CD8+ and CD4+ T-cells (PubMed:24687959). In intestinal CD4+ T-cells, expression of gut-retention molecules Itgae/CD103 and Cd69, and gut-homing molecule Ccr9 is reduced (PubMed:24687959). Development of lymphocytes and myeloid cells is normal (PubMed:18329370, PubMed:19752223). However, in older mice, the number of CD4+ and CD8+ T-cells is increased in lymph nodes and blood (PubMed:18329370). Susceptible to oral infection with bacterium C.rodentium resulting in higher bacteria load in the colon and spleen (PubMed:18329370). However, in another study, the mice were not susceptible to oral infection with bacterium C.rodentium (PubMed:24687959). Impaired immune response following intranasal infection with influenza virus caused by a decrease in the number of antigen-specific CD8+ T-cells in the infected lung (PubMed:19752223). However, the capacity of CD8+ T-cells to kill infected cells is not affected (PubMed:19752223). Increased resistance to oral infection with intracellular parasite T.gondii caused by a reduced number of IL17-producing CD4+ T-cells resulting in enhanced clearance of the parasite (PubMed:24687959). {ECO:0000269|PubMed:18329370, ECO:0000269|PubMed:19752223, ECO:0000269|PubMed:24687959}. |