| 55992 | Q9R1R2 | TRIM3_MOUSE | Tripartite motif-containing protein 3 (EC 2.3.2.27) (RING finger protein 22) (RING finger protein HAC1) | DISRUPTION PHENOTYPE | Trim3-knockout mice are viable, fertile and showed no obvious morphological abnormalities (PubMed:24086586). However, they display increased levels of gamma-actin at hippocampal synapses, resulting in higher spine densities, increased long-term potentiation, and enhanced short-term contextual fear memory consolidation (PubMed:26527743). In addition, they express lower levels of antiviral genes and show lower levels of inflammatory response following poly(I:C) but not lipopolysaccharide (LPS) stimulation (PubMed:32878999). {ECO:0000269|PubMed:24086586, ECO:0000269|PubMed:26527743, ECO:0000269|PubMed:32878999}. |