| 56480 | Q9WUN2 | TBK1_MOUSE | Serine/threonine-protein kinase TBK1 (EC 2.7.11.1) (T2K) (TANK-binding kinase 1) | DISRUPTION PHENOTYPE | Mice display embryonic lethality at 14.5 dpc due to massive liver degeneration and apoptosis. Embryonic fibroblasts from mice lacking Tbk1 exhibit dramatically reduced transcription of NF-kappa-B, as well as marked defects in interferon alpha and beta, and RANTES gene expression after infection with Sendai or Newcastle disease virus. {ECO:0000269|PubMed:10990461, ECO:0000269|PubMed:14679297, ECO:0000269|PubMed:15210742}. |