| 56532 | Q9QZL0 | RIPK3_MOUSE | Receptor-interacting serine/threonine-protein kinase 3 (EC 2.7.11.1) (RIP-like protein kinase 3) (Receptor-interacting protein 3) (RIP-3) (mRIP3) | DISRUPTION PHENOTYPE | No visible phenotype in normal conditions; mice are viable and indistinguishable from wild-type mice (PubMed:14749364, PubMed:24557836). Mice are resistant to TNF-induced hypothermia (PubMed:24557836). Mice are more susceptible to influenza A virus (IAV) infection than wild-type mice: at a modestly lethal dose of IAV, mice display significantly increased rates of mortality, probably caused by a failure to eliminate infected cells and limit virus spread in pulmonary tissue (PubMed:27321907, PubMed:32200799). Perinatal lethality observed in Ripk1 knockout mice is rescued in knockout mice lacking both Ripk1 and Ripk3; mice however die the first days of postnatal life (PubMed:24813849, PubMed:24813850, PubMed:27819681, PubMed:27819682). Only mice lacking Ripk1, Ripk3 and Casp8 survive past weaning and rescue lethality caused by the absence of Ripk1 (PubMed:24813849, PubMed:24813850). {ECO:0000269|PubMed:14749364, ECO:0000269|PubMed:24557836, ECO:0000269|PubMed:24813849, ECO:0000269|PubMed:24813850, ECO:0000269|PubMed:27321907, ECO:0000269|PubMed:27819681, ECO:0000269|PubMed:27819682, ECO:0000269|PubMed:32200799}. |