Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:58998
  • Symbol:Nectin3
  • Description:nectin cell adhesion molecule 3
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Gene ID Entry Entry Name Protein Name Type Information
58998 Q9JLB9 NECT3_MOUSE Nectin-3 (Nectin cell adhesion molecule 3) (Poliovirus receptor-related protein 3) (CD antigen CD113) DISRUPTION PHENOTYPE Mice show an ocular phenotype, microphthalmia, accompanied by a separation of the contact between the pigment and non-pigment cell layers of the ciliary epithelia. Male mice exhibits infertility, suggesting a role in spermatogenesis. In the hippocampus, the formation and the number of adherens junctions at the synapses is impaired, and the trajectory of mossy fiber is abnormal. {ECO:0000269|PubMed:15728677, ECO:0000269|PubMed:16300961}.