Mine Disruption Phenotype

Gene Info

  • Species:Mouse (Mus musculus)
  • GeneID:636931
  • Symbol:Trim71
  • Description:tripartite motif-containing 71
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Gene ID Entry Entry Name Protein Name Type Information
636931 Q1PSW8 LIN41_MOUSE E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (mLin41) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) DISRUPTION PHENOTYPE Embryonic lethality at 9.5 dpc, due to a neural tube closure defect in the anterior craniofacial region of the neural tube, corresponding to the forebrain/midbrain boundary. Reduced cell proliferation in the neuroepithelium. {ECO:0000269|PubMed:19098426, ECO:0000269|PubMed:22508726, ECO:0000269|PubMed:25883935}.