| 65964 | Q9ESL4 | M3K20_MOUSE | Mitogen-activated protein kinase kinase kinase 20 (EC 2.7.11.25) (Leucine zipper- and sterile alpha motif kinase ZAK) (Leucine zipper- and sterile alpha motif-containing kinase) (MLK-like mitogen-activated protein triple kinase) (Mitogen-activated protein | DISRUPTION PHENOTYPE | Knockout results in fully penetrant lethality at 9.5 dpc due to severe cardiac edema and growth retardation (PubMed:26755636). Embryos show polydactyly of the feet (PubMed:26755636). Defects in stress-activated protein kinase signaling cascade in response to ribotoxic stress, leading to impaired activation of the JNK and MAP kinase p38 pathways (PubMed:27598200). {ECO:0000269|PubMed:26755636, ECO:0000269|PubMed:27598200}. |